Pharmacological effect of Astelin Nasal Spray
Astelin Nasal Spray H1-histamine blockers, has antihistamine, anti-allergic effect and membrane reduces the permeability of the capillaries and exudation, stabilizes mast cell membranes and prevents the release of these biologically active substances (histamine, serotonin, leukotrienes, a factor that activates platelets, etc.) that cause bronchospasm and promote development of early and late stage of allergic reactions and inflammation. When intranasal administration reduces itching and nasal congestion, sneezing and rhinorrhea. The weakening of symptoms of allergic rhinitis is noted for 3 h. The effect reaches a maximum after 4-5 h and lasts for 12 h. The instillation into the conjunctival sac – reducing symptoms of allergic eye inflammation (redness, pain, itching, watery eyes, swelling of the eyelids). The effect is manifested after 10 minutes and lasts for 12 hours is not carcinogenic and mutagenic. When administered a dose of 550 times greater than recommended for intranasal application in mice has embryotoxic, teratogenic and fetotoksicheskoe (external defects and abnormalities of the skeleton).
Indications Astelin Nasal Spray
Allergic rhinitis (seasonal and year-round) allergic conjunctivitis.
Contra Astelin Nasal Spray
Hypersensitivity, pregnancy (especially the I trimester), lactation, infancy (up to 6 years – nasal spray, up to 4 years old – eye drops). C carefully. Renal insufficiency (nasal spray).
Side effects of Astelin Nasal Spray
Allergic reactions: skin rash, hives, itching.
The respiratory system: sneezing fits, sore throat, cough, shortness of breath, feeling of tightness in the chest, shortness of breath, bronchospasm.
Nervous system disorders: headache, dizziness, excessive fatigue, sleepiness (especially when using a nasal spray).
From the digestive system: vomiting, loss of appetite, thirst, bitter taste in the mouth, change in taste, dry mouth, nausea, gastralgia (crowding in the head during intranasal administration).
Other: tachycardia, hematuria, myalgia, weight gain.
Local reactions (using a nasal spray): irritation, dryness, burning or itching of nasal mucosa, rarely – nosebleeds.
When using the eye drops: irritation of the conjunctiva, rarely – dry eyes, tearing, foreign body sensation or pain in the eye, swelling, chemosis, hemorrhage into the anterior chamber of the eye, keratopathy, keratitis, erosion, or excoriation of the cornea, blurred vision, blefarit.Peredozirovka.
Symptoms: probable hypersomnia.
Treatment: symptomatic.
Dosage and administration Astelin Nasal Spray
Intranasal (pre-clearing the nasal passages) – 1 dose aerosol (0.14 mg/0.14 ml) in each course nososovoy 1-2 times a day (not recommended crowding the head). Conjunctival – 1 cap in each eye 3-4 times a day.
Cautions Astelin Nasal Spray
When applying eye drops is not recommended to wear contact lenses. During the treatment necessary to avoid the use of ethanol and the use of drugs which depress the central nervous system. Keep in mind the possibility of dizziness and drowsiness.
Interaction Astelin Nasal Spray
Enhances the sedative effect of ethanol and other drugs that depress the central nervous system. Ketoconazole decreases and cimetidine increases the concentration of azelastine in the plasma.
Increases (relatively) a sedative effect of alcohol and other central depressant drug. Ketoconazole prevents the determination of the concentration of azelastine in blood plasma, and cimetidine, inhibiting cytochrome P450, it increases.
